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ea0019p56 | Clinical practice/governance and case reports | SFEBES2009

Pituitary ACTH-dependent Cushing’s syndrome caused by ectopic CRF secretion from an intra-adrenal phaeochromocytoma

Woods D , Arutchealvam V , Madathil A , Peaston R , Turner S , Neely RDG , Graham J , Richardson D , Lennard TJW , Bliss R , Bennett SB , Johnson S , Mason JI , Quinton R

A 69-year-old woman was admitted with new uncontrolled diabetes, severe hypertension and bilateral leg oedema. Cushings syndrome was suspected when she developed resistant hypokalemic alkalosis on diuretic therapy. Detailed questioning also revealed a history of episodic sweating, palpitation and tremor.Investigation & management: ACTH-dependant Cushings syndrome was confirmed: Serum ACTH 516 ng/l; urine free cortisol 20 045 nmol/24 h; 09...

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ea0011p526 | Endocrine tumours and neoplasia | ECE2006

Estrone and cortisol co-secreting adrenocortical carcinoma in a man presenting with hypogonadotrophic hypogonadism and painful gynaecomastia

Lim EL , Razvi S , Vaikkakara S , Ibrahim IM , Turner S , Johnson S , Mason JI , Lennard TJW , Bliss R , Elloitt S , Richardson D , Neely RD , Quinton R

Case report: A 56-year old man presented with a 3 month history of painful bilateral gynaecomastia and sexual dysfunction. Investigations revealed hypogonadotrophic hypogonadism with markedly elevated serum E2, but otherwise normal baseline anterior pituitary function. Tumour markers were negative and adrenal androgens and LFTs were normal. Imaging identified a ∼6 cm right adrenal mass. Preoperative workup excluded phaechromocytoma, but identified low-grade, ACTH-indepen...

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Endocrine Abstracts

Pituitary ACTH-dependent Cushing’s syndrome caused by ectopic CRF secretion from an intra-adrenal phaeochromocytoma

Estrone and cortisol co-secreting adrenocortical carcinoma in a man presenting with hypogonadotrophic hypogonadism and painful gynaecomastia

BiosciAbstracts